CHEN Xiaoxue, LI Ran, ZHU Huijuan, LU Lin. Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency[J]. Journal of Rare Diseases, 2023, 2(3): 436-441. DOI: 10.12376/j.issn.2097-0501.2023.03.016
Citation: CHEN Xiaoxue, LI Ran, ZHU Huijuan, LU Lin. Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency[J]. Journal of Rare Diseases, 2023, 2(3): 436-441. DOI: 10.12376/j.issn.2097-0501.2023.03.016

Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency

Funds: 

Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences 2021-I2M-C&T-B-001

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  • Corresponding author:

    LU Lin, E-mail: lulin88@sina.com

  • Received Date: June 16, 2023
  • Accepted Date: September 25, 2023
  • Available Online: September 08, 2023
2097-0501/©2023 Editorial Office of Journal of Rare Diseases This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)
  • Adrenal insufficiency is a disease characterized by insufficient secretion of adrenocortical hormones, usually treated with glucocorticoid replacement therapy. The routine drugs have two forms-short-acting and long-acting. The shorter one should be taken 2-3 times a day resulting hormone level of patients fluctuating greatly within a day. Although long-acting drugs reduce the frequency of administration, it is easy to lead to excessive replacement, resulting in adverse effects on metabolism. New alternative treatments for adult patients have emerged, including modified-release hydrocortisone and hydrocortisone subcutaneous infusion pumps. In this review, we briefly introduce these new therapies, emphasizing the pharmacodynamics and pharmacokinetics of the replacement, the effects on metabolism and drug safety, aiming at contributing to the future clinical practice.

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