NIE Zhimei, DOU Jianxin, DU Jin, GU Weijun, LYU Zhaohui, DOU Jingtao, MU Yiming. Irregular Menstruation-Hirsutism-Infertility: Clinical Management of Non-Classic Congenital Adrenal Hyperplasia[J]. Journal of Rare Diseases, 2023, 2(3): 420-426. DOI: 10.12376/j.issn.2097-0501.2023.03.013
Citation: NIE Zhimei, DOU Jianxin, DU Jin, GU Weijun, LYU Zhaohui, DOU Jingtao, MU Yiming. Irregular Menstruation-Hirsutism-Infertility: Clinical Management of Non-Classic Congenital Adrenal Hyperplasia[J]. Journal of Rare Diseases, 2023, 2(3): 420-426. DOI: 10.12376/j.issn.2097-0501.2023.03.013

Irregular Menstruation-Hirsutism-Infertility: Clinical Management of Non-Classic Congenital Adrenal Hyperplasia

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  • Corresponding author:

    LYU Zhaohui, E-mail: metabolism301@126.com

  • Received Date: May 05, 2023
  • Accepted Date: June 03, 2023
  • Available Online: September 08, 2023
2097-0501/©2023 Editorial Office of Journal of Rare Diseases This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)
  • A 38-year-old female presented with irregular menstruation and hirsutism that started at age of 16 and diagnosed with polycystic ovary syndrome at age of 29 with elevated testosterone. When treated with ethinestradiol cyproterone tablets, her menstruation returned to normal and androgen levels was not changed. At age of 38 she was referred to the hospital with infertility, a diagnosis of nonclassical 21-hydroxylase deficiency was confirmed using 17-hydroxyprogesterone, dehydroepiandrosterone-sulfate, a cosyntropin-stimulation test and genetic test. This case suggested that nonclassical congenital adrenal hyperplasia should be considered when a patient is presented with oligomenorrhea, hirsutism with hyperandrogenemia and infertility.

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