Irregular Menstruation-Hirsutism-Infertility: Clinical Management of Non-Classic Congenital Adrenal Hyperplasia

NIE Zhimei; DOU Jianxin; DU Jin; GU Weijun; LYU Zhaohui; DOU Jingtao; MU Yiming

doi:10.12376/j.issn.2097-0501.2023.03.013

Journal of Rare Diseases > 2023 > 2(3): 420-426. > DOI: 10.12376/j.issn.2097-0501.2023.03.013

NIE Zhimei, DOU Jianxin, DU Jin, GU Weijun, LYU Zhaohui, DOU Jingtao, MU Yiming. Irregular Menstruation-Hirsutism-Infertility: Clinical Management of Non-Classic Congenital Adrenal Hyperplasia[J]. Journal of Rare Diseases, 2023, 2(3): 420-426. DOI: 10.12376/j.issn.2097-0501.2023.03.013

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Irregular Menstruation-Hirsutism-Infertility: Clinical Management of Non-Classic Congenital Adrenal Hyperplasia

1.
Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
2.
Department of Endocrinology, Weifang People′s Hospital in Shandong Province, Weifang 261041, China

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Corresponding author:
LYU Zhaohui, E-mail: metabolism301@126.com
Received Date: May 05, 2023
Accepted Date: June 03, 2023
Available Online: September 08, 2023

Graphical Abstract

Abstract

Abstract

A 38-year-old female presented with irregular menstruation and hirsutism that started at age of 16 and diagnosed with polycystic ovary syndrome at age of 29 with elevated testosterone. When treated with ethinestradiol cyproterone tablets, her menstruation returned to normal and androgen levels was not changed. At age of 38 she was referred to the hospital with infertility, a diagnosis of nonclassical 21-hydroxylase deficiency was confirmed using 17-hydroxyprogesterone, dehydroepiandrosterone-sulfate, a cosyntropin-stimulation test and genetic test. This case suggested that nonclassical congenital adrenal hyperplasia should be considered when a patient is presented with oligomenorrhea, hirsutism with hyperandrogenemia and infertility.
- nonclassical 21-hydroxylase deficiency,
- 17-hydroxyprogesterone,
- cosyntropin-stimulation test

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References (27)

References

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Irregular Menstruation-Hirsutism-Infertility: Clinical Management of Non-Classic Congenital Adrenal Hyperplasia