A Young Hemophilia Patient with Advanced Hemophilic Arthritis and HIV Infection

CAI Huacong; FENG Bin; CAO Wei; LIU Shufen; YUAN Tao; ZHANG Yan; LI Kuixing; ZHAO Yongqiang; WANG Shujie

doi:10.12376/j.issn.2097-0501.2022.04.008

Journal of Rare Diseases > 2022 > 1(4): 407-412. > DOI: 10.12376/j.issn.2097-0501.2022.04.008

CAI Huacong, FENG Bin, CAO Wei, LIU Shufen, YUAN Tao, ZHANG Yan, LI Kuixing, ZHAO Yongqiang, WANG Shujie. A Young Hemophilia Patient with Advanced Hemophilic Arthritis and HIV Infection[J]. Journal of Rare Diseases, 2022, 1(4): 407-412. DOI: 10.12376/j.issn.2097-0501.2022.04.008

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A Young Hemophilia Patient with Advanced Hemophilic Arthritis and HIV Infection

1.
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2.
Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
3.
Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
4.
Department of Physical Medicine and Rehabilitation, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
5.
Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
6.
Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

Corresponding author:
WANG Shujie, E-mail: wsj0630@sina.com
Received Date: August 16, 2022
Accepted Date: September 13, 2022
Available Online: December 22, 2022

Graphical Abstract

Abstract

Abstract

A young male diagnosed with severe hemophilia A since childhood, was presented with recurrent joint and urinary bleeding. Annualized bleed rates dropped below five with low dose prophylactic medication.Bleeding in the right knee joint recently aggravated. Due to coexisting HIV infection and advanced hemophilic arthritis, the patient was managed by a multi-disciplinary team(MDT).Total knee arthroplasty was performed by an experienced surgeon using modern prosthesis design and intraoperative navigation technologies.Physical and rehabilitation therapy was provided during the postoperative period, and joint function improved. The MDT managed the young patient with HIV infection and advanced hemophilic arthritis. The patient was diagnosed with osteoporosis thought to have been caused by hemophilia, HIV infection and antiviral drugs; and he received treatment. The treatment of this patient reflects the importance of multidisciplinary cooperation in the management of difficult and rare diseases.
- hemophilia,
- arthritis,
- HIV,
- osteoporosis

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References (5)

References

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A Young Hemophilia Patient with Advanced Hemophilic Arthritis and HIV Infection