An Early Onset of Myocardial Infarction Patient with Syphilis and Familial Hypercholesterolemia
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摘要: 梅毒感染可以引起心血管系统受累,但冠状动脉受累是较为少见的临床表现。家族性高胆固醇血症(FH)是一种因低密度脂蛋白胆固醇(LDL-C)清除障碍导致LDL-C水平显著升高,造成早发严重动脉粥样硬化的常染色体显性遗传疾病。本文报道一例梅毒感染合并FH的青年男性患者,临床表现为急性心肌梗死、高LDL-C血症,冠脉造影及腔内影像检查可见冠状动脉多发瘤样扩张和狭窄,经反复冠状动脉药物球囊扩张后短期内再狭窄,最终植入支架治疗。Abstract: Syphilis may affect the cardiovascular system, in which coronary arteries are less commonly involved. Familial hypercholesterolemia (FH) is an autosomal dominant inherited disease with elevated low-density lipoprotein-cholesterol (LDL-C) levels due to impaired LDL-C clearance. We report a young male patient with syphilis and FH. The clinical manifestations were acute myocardial infarction and high LDL-C levels. Coronary angiography and intracoronary imaging showed multiple aneurysmal ectasia and stenosis. A drug-eluting stent was implemented when recurrent restenosis occurred after two percutaneous coronary drug-eluting balloon angioplasties.
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