抗神经抗体在神经精神狼疮中的研究进展

Research Progress in Antibodies Related to Autoimmune Encephalitis in Neuropsychiatric Systemic Lupus Erythematosus

摘要: 抗神经抗体是神经精神狼疮(NPSLE)潜在的诊断标志物之一，这些抗神经抗体包括抗神经元抗体与抗神经胶质细胞抗体。抗神经元抗体又分为抗神经元表面蛋白抗体和其他抗神经元细胞内蛋白抗体，前者以抗N-甲基-D-天冬氨酸受体(NMDAR)抗体为代表。本文对NPSLE相关抗神经抗体进行分类阐述。

Abstract: Several anti-neural antibodies are associated with neuropsychiatric systemic lupus erythematosus (NPSLE) including anti-neuronal antibodies and anti-glial cell antibodies. The anti-neuronal antibodies has two types: anti-neuronal surface protein antibodies represented by anti-N-methyl-D-aspartate receptor (NMDAR) antibodies, and anti-neuronal intracellular protein antibodies. In this paper, we review and classify the anti-neural antibodies related to NPSLE.