Abstract: Hereditary angioedema (HAE) is a rare autosomal dominant disorder characterized by recurrent, unpredictable episodes of skin and mucosal edema, which may affect the face, extremities, respiratory tract, gastrointestinal tract, and genitals, with a global prevalence of approximately 1 in 50 000. This case report presents a young female patient with a history of recurrent abdominal pain and multisite edema. During an acute episode, laboratory tests revealed decreased complement C4 levels along with reduced concentration and function of C1 esterase inhibitor. Computed tomography (CT) demonstrated bowel wall edema and pelvic effusion. Previously undiagnosed, the patient was admitted for this acute attack and was ultimately diagnosed with HAE following a multidisciplinary treatment(MDT)team discussion at our hospital. The rapid diagnosis and treatment of this case highlight the critical role of MDT in the management of complex and rare diseases.