刘婷红, 袁柳, 徐金山, 王旸烁, 梁树立. 迷走神经刺激治疗Dravet综合征一例[J]. 罕见病研究, 2022, 1(3): 318-324. DOI: 10.12376/j.issn.2097-0501.2022.03.014
引用本文: 刘婷红, 袁柳, 徐金山, 王旸烁, 梁树立. 迷走神经刺激治疗Dravet综合征一例[J]. 罕见病研究, 2022, 1(3): 318-324. DOI: 10.12376/j.issn.2097-0501.2022.03.014
LIU Tinghong, YUAN Liu, XU Jinshan, WANG Yangshuo, LIANG Shuli. Vagus Nerve Stimulation in the Treatment of Dravet Syndrome[J]. Journal of Rare Diseases, 2022, 1(3): 318-324. DOI: 10.12376/j.issn.2097-0501.2022.03.014
Citation: LIU Tinghong, YUAN Liu, XU Jinshan, WANG Yangshuo, LIANG Shuli. Vagus Nerve Stimulation in the Treatment of Dravet Syndrome[J]. Journal of Rare Diseases, 2022, 1(3): 318-324. DOI: 10.12376/j.issn.2097-0501.2022.03.014

迷走神经刺激治疗Dravet综合征一例

Vagus Nerve Stimulation in the Treatment of Dravet Syndrome

  • 摘要: Dravet综合征是一种儿童期起病的癫痫综合征,表现为药物难治性癫痫,并常出现癫痫持续状态,随病程进展出现认知和语言损害。抗癫痫发作药物治疗和切除性癫痫手术治疗对Dravet综合征治疗效果差,神经调控手术,特别是迷走神经刺激是有效、可行的治疗方案。现报道迷走神经刺激治疗Dravet综合征病例一例,一年随访癫痫发作减少大于50%。同时,进行了相关文献复习和总结,共收集已报道的迷走神经刺激术治疗Dravet病例141例,总体癫痫控制有效率为53.9%。

     

    Abstract: Dravet syndrome is a epileptic syndrome characterized by drug-resistant epilepsy occuring at childhood. It is often accompanied by status epilepticus and cognitive and language impairment appearing gradually as the disease progresses. The effect of antiepileptic drugs and resection epilepsy surgery on Dravet syndrome is poor although neuromodulation surgery, especially vagus nerve stimulation, is an effective and feasible treatment for Dravet syndrome. In this article we reported a case of Dravet syndrome treated with vagus nerve stimulation, relevant literature was reviewed and summarized at the same time. A total of 141 cases of Dravet treated by vagus nerve stimulation were collected, and the overall effective rate was 53.9%.

     

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